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Home - Products - GPCR/G Protein - Somatostatin Receptor - CYN 154806 TFA

CYN 154806 TFA

CAS No. 2828432-46-6

CYN 154806 TFA( —— )

Catalog No. M37914 CAS No. 2828432-46-6

CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CYN 154806 TFA
  • Note
    Research use only, not for human use.
  • Brief Description
    CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively.
  • Description
    CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
  • In Vitro
    CYN 154806 TFA inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 TFA also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively).
  • In Vivo
    CYN 154806 TFA (0.1 mg/kg; i.p.; 20 minbefore the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Somatostatin Receptor
  • Recptor
    Somatostatin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2828432-46-6
  • Formula Weight
    1311.36
  • Molecular Formula
    C58H69F3N12O16S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 25 mg/mL (19.06 mM; Ultrasonic)
  • SMILES
    C[C@@H](O)[C@H]1C(N[C@H](C(N[C@@H](C(N)=O)CC2=CC=C(O)C=C2)=O)CSSC[C@@H](NC([C@@H](NC(C)=O)CC3=CC=C([N+]([O-])=O)C=C3)=O)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@H](CC5=CNC6=CC=CC=C65)C(N[C@@H](CCCCN)C(N1)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15.?
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  • CYN 154806

    CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist, The pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.

  • CYN 154806 TFA

    CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively.

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